{"R-HSA-1059683": "Interleukin-6 signaling", "R-HSA-110056": "MAPK3 (ERK1) activation", "R-HSA-112409": "RAF-independent MAPK1/3 activation", "R-HSA-112411": "MAPK1 (ERK2) activation", "R-HSA-1266738": "Developmental Biology", "R-HSA-1280215": "Cytokine Signaling in Immune system", "R-HSA-1500931": "Cell-Cell communication", "R-HSA-162582": "Signal Transduction", "R-HSA-1643685": "Disease", "R-HSA-168256": "Immune System", "R-HSA-212436": "Generic Transcription Pathway", "R-HSA-2262752": "Cellular responses to stress", "R-HSA-2559582": "Senescence-Associated Secretory Phenotype (SASP)", "R-HSA-2559583": "Cellular Senescence", "R-HSA-381426": "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)", "R-HSA-392499": "Metabolism of proteins", "R-HSA-418990": "Adherens junctions interactions", "R-HSA-421270": "Cell-cell junction organization", "R-HSA-446728": "Cell junction organization", "R-HSA-449147": "Signaling by Interleukins", "R-HSA-5663205": "Infectious disease", "R-HSA-5683057": "MAPK family signaling cascades", "R-HSA-5684996": "MAPK1/MAPK3 signaling", "R-HSA-597592": "Post-translational protein modification", "R-HSA-6783589": "Interleukin-6 family signaling", "R-HSA-6783783": "Interleukin-10 signaling", "R-HSA-6785807": "Interleukin-4 and Interleukin-13 signaling", "R-HSA-73857": "RNA Polymerase II Transcription", "R-HSA-74160": "Gene expression (Transcription)", "R-HSA-8853884": "Transcriptional Regulation by VENTX", "R-HSA-8953897": "Cellular responses to stimuli", "R-HSA-8957275": "Post-translational protein phosphorylation", "R-HSA-9658195": "Leishmania infection", "R-HSA-9660821": "ADORA2B mediated anti-inflammatory cytokines production", "R-HSA-9662834": "CD163 mediating an anti-inflammatory response", "R-HSA-9662851": "Anti-inflammatory response favouring Leishmania parasite infection", "R-HSA-9664433": "Leishmania parasite growth and survival", "R-HSA-9734767": "Developmental Cell Lineages", "R-HSA-9824443": "Parasitic Infection Pathways", "R-HSA-9958825": "Activation of STAT3 by cadherin engagement", "R-HSA-9968734": "Differentiation of Circulating Monocytes", "R-HSA-1257604": "PIP3 activates AKT signaling", "R-HSA-1430728": "Metabolism", "R-HSA-163685": "Integration of energy metabolism", "R-HSA-186712": "Regulation of beta-cell development", "R-HSA-199418": "Negative regulation of the PI3K/AKT network", "R-HSA-199977": "ER to Golgi Anterograde Transport", "R-HSA-199991": "Membrane Trafficking", "R-HSA-210745": "Regulation of gene expression in beta cells", "R-HSA-264876": "Insulin processing", "R-HSA-2980736": "Peptide hormone metabolism", "R-HSA-422085": "Synthesis, secretion, and deacylation of Ghrelin", "R-HSA-422356": "Regulation of insulin secretion", "R-HSA-446203": "Asparagine N-linked glycosylation", "R-HSA-5653656": "Vesicle-mediated transport", "R-HSA-6807878": "COPI-mediated anterograde transport", "R-HSA-6811558": "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling", "R-HSA-74713": "IRS activation", "R-HSA-74749": "Signal attenuation", "R-HSA-74751": "Insulin receptor signalling cascade", "R-HSA-74752": "Signaling by Insulin receptor", "R-HSA-77387": "Insulin receptor recycling", "R-HSA-9006925": "Intracellular signaling by second messengers", "R-HSA-9006934": "Signaling by Receptor Tyrosine Kinases", "R-HSA-948021": "Transport to the Golgi and subsequent modification", "R-HSA-9614085": "FOXO-mediated transcription", "R-HSA-9615017": "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes", "R-HSA-9634815": "Transcriptional Regulation by NPAS4", "R-HSA-9768919": "NPAS4 regulates expression of target genes", "R-HSA-977225": "Amyloid fiber formation", "R-HSA-109582": "Hemostasis", "R-HSA-114608": "Platelet degranulation ", "R-HSA-159418": "Recycling of bile acids and salts", "R-HSA-174824": "Plasma lipoprotein assembly, remodeling, and clearance", "R-HSA-1852241": "Organelle biogenesis and maintenance", "R-HSA-189445": "Metabolism of porphyrins", "R-HSA-189451": "Heme biosynthesis", "R-HSA-189483": "Heme degradation", "R-HSA-194068": "Bile acid and bile salt metabolism", "R-HSA-2168880": "Scavenging of heme from plasma", "R-HSA-2173782": "Binding and Uptake of Ligands by Scavenger Receptors", "R-HSA-382551": "Transport of small molecules", "R-HSA-556833": "Metabolism of lipids", "R-HSA-5617833": "Cilium Assembly", "R-HSA-5620912": "Anchoring of the basal body to the plasma membrane", "R-HSA-76002": "Platelet activation, signaling and aggregation", "R-HSA-76005": "Response to elevated platelet cytosolic Ca2+", "R-HSA-8957322": "Metabolism of steroids", "R-HSA-8963899": "Plasma lipoprotein remodeling", "R-HSA-8964058": "HDL remodeling", "R-HSA-9707564": "Cytoprotection by HMOX1", "R-HSA-9711123": "Cellular response to chemical stress", "R-HSA-9748784": "Drug ADME", "R-HSA-9749641": "Aspirin ADME", "R-HSA-9757110": "Prednisone ADME", "R-HSA-9793528": "Ciprofloxacin ADME", "R-HSA-9975921": "Assembly of the 9+0 primary cilium", "R-HSA-1227986": "Signaling by ERBB2", "R-HSA-1227990": "Signaling by ERBB2 in Cancer", "R-HSA-1236382": "Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants", "R-HSA-1236394": "Signaling by ERBB4", "R-HSA-1250196": "SHC1 events in ERBB2 signaling", "R-HSA-1251932": "PLCG1 events in ERBB2 signaling", "R-HSA-157118": "Signaling by NOTCH", "R-HSA-1643713": "Signaling by EGFR in Cancer", "R-HSA-177929": "Signaling by EGFR", "R-HSA-179812": "GRB2 events in EGFR signaling", "R-HSA-180292": "GAB1 signalosome", "R-HSA-180336": "SHC1 events in EGFR signaling", "R-HSA-182971": "EGFR downregulation", "R-HSA-1963640": "GRB2 events in ERBB2 signaling", "R-HSA-1963642": "PI3K events in ERBB2 signaling", "R-HSA-212718": "EGFR interacts with phospholipase C-gamma", "R-HSA-2179392": "EGFR Transactivation by Gastrin", "R-HSA-2219528": "PI3K/AKT Signaling in Cancer", "R-HSA-2219530": "Constitutive Signaling by Aberrant PI3K in Cancer", "R-HSA-372790": "Signaling by GPCR", "R-HSA-373760": "L1CAM interactions", "R-HSA-388396": "GPCR downstream signalling", "R-HSA-416476": "G alpha (q) signalling events", "R-HSA-422475": "Axon guidance", "R-HSA-445144": "Signal transduction by L1", "R-HSA-5637810": "Constitutive Signaling by EGFRvIII", "R-HSA-5637812": "Signaling by EGFRvIII in Cancer", "R-HSA-5637815": "Signaling by Ligand-Responsive EGFR Variants in Cancer", "R-HSA-5638302": "Signaling by Overexpressed Wild-Type EGFR in Cancer", "R-HSA-5638303": "Inhibition of Signaling by Overexpressed EGFR", "R-HSA-5663202": "Diseases of signal transduction by growth factor receptors and second messengers", "R-HSA-5673001": "RAF/MAP kinase cascade", "R-HSA-6785631": "ERBB2 Regulates Cell Motility", "R-HSA-881907": "Gastrin-CREB signalling pathway via PKC and MAPK", "R-HSA-8847993": "ERBB2 Activates PTK6 Signaling", "R-HSA-8848021": "Signaling by PTK6", "R-HSA-8856825": "Cargo recognition for clathrin-mediated endocytosis", "R-HSA-8856828": "Clathrin-mediated endocytosis", "R-HSA-8857538": "PTK6 promotes HIF1A stabilization", "R-HSA-8863795": "Downregulation of ERBB2 signaling", "R-HSA-8864260": "Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors", "R-HSA-8866910": "TFAP2 (AP-2) family regulates transcription of growth factors and their receptors", "R-HSA-8939211": "ESR-mediated signaling", "R-HSA-9006927": "Signaling by Non-Receptor Tyrosine Kinases", "R-HSA-9006931": "Signaling by Nuclear Receptors", "R-HSA-9009391": "Extra-nuclear estrogen signaling", "R-HSA-9012852": "Signaling by NOTCH3", "R-HSA-9013507": "NOTCH3 Activation and Transmission of Signal to the Nucleus", "R-HSA-9609646": "HCMV Infection", "R-HSA-9609690": "HCMV Early Events", "R-HSA-9634638": "Estrogen-dependent nuclear events downstream of ESR-membrane signaling", "R-HSA-9664565": "Signaling by ERBB2 KD Mutants", "R-HSA-9665348": "Signaling by ERBB2 ECD mutants", "R-HSA-9665686": "Signaling by ERBB2 TMD/JMD mutants", "R-HSA-9675108": "Nervous system development", "R-HSA-9734779": "Developmental Cell Lineages of the Integumentary System", "R-HSA-9820952": "Respiratory Syncytial Virus Infection Pathway", "R-HSA-9820960": "Respiratory syncytial virus (RSV) attachment and entry", "R-HSA-9824446": "Viral Infection Pathways", "R-HSA-9924644": "Developmental Lineages of the Mammary Gland", "R-HSA-9927432": "Developmental Lineage of Mammary Gland Myoepithelial Cells", "R-HSA-381340": "Transcriptional regulation of white adipocyte differentiation", "R-HSA-5357786": "TNFR1-induced proapoptotic signaling", "R-HSA-5357905": "Regulation of TNFR1 signaling", "R-HSA-5357956": "TNFR1-induced NF-kappa-B signaling pathway", "R-HSA-5626978": "TNFR1-mediated ceramide production", "R-HSA-5668541": "TNFR2 non-canonical NF-kB pathway", "R-HSA-73887": "Death Receptor Signaling", "R-HSA-75893": "TNF signaling", "R-HSA-9843745": "Adipogenesis", "R-HSA-9942503": "Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells)", "R-HSA-9945266": "Differentiation of T cells", "R-HSA-1251985": "Nuclear signaling by ERBB4", "R-HSA-196854": "Metabolism of vitamins and cofactors", "R-HSA-2187338": "Visual phototransduction", "R-HSA-3000480": "Scavenging by Class A Receptors", "R-HSA-6806667": "Metabolism of fat-soluble vitamins", "R-HSA-8963888": "Chylomicron assembly", "R-HSA-8963898": "Plasma lipoprotein assembly", "R-HSA-8963901": "Chylomicron remodeling", "R-HSA-8964026": "Chylomicron clearance", "R-HSA-8964043": "Plasma lipoprotein clearance", "R-HSA-9024446": "NR1H2 and NR1H3-mediated signaling", "R-HSA-9029569": "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux", "R-HSA-9709957": "Sensory Perception", "R-HSA-975634": "Retinoid metabolism and transport", "R-HSA-166658": "Complement cascade", "R-HSA-166663": "Initial triggering of complement", "R-HSA-166786": "Creation of C4 and C2 activators", "R-HSA-168249": "Innate Immune System", "R-HSA-173623": "Classical antibody-mediated complement activation", "R-HSA-1234158": "Regulation of gene expression by Hypoxia-inducible Factor", "R-HSA-1234174": "Cellular response to hypoxia", "R-HSA-194138": "Signaling by VEGF", "R-HSA-194313": "VEGF ligand-receptor interactions", "R-HSA-195399": "VEGF binds to VEGFR leading to receptor dimerization", "R-HSA-4420097": "VEGFA-VEGFR2 Pathway", "R-HSA-5218921": "VEGFR2 mediated cell proliferation", "R-HSA-9679191": "Potential therapeutics for SARS", "R-HSA-9679506": "SARS-CoV Infections", "R-HSA-2404192": "Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)", "R-HSA-2428924": "IGF1R signaling cascade", "R-HSA-2428928": "IRS-related events triggered by IGF1R", "R-HSA-2428933": "SHC-related events triggered by IGF1R", "R-HSA-1474244": "Extracellular matrix organization", "R-HSA-1566948": "Elastic fibre formation", "R-HSA-168255": "Influenza Infection", "R-HSA-168277": "Influenza Virus Induced Apoptosis", "R-HSA-170834": "Signaling by TGF-beta Receptor Complex", "R-HSA-202733": "Cell surface interactions at the vascular wall", "R-HSA-2129379": "Molecules associated with elastic fibres", "R-HSA-2173788": "Downregulation of TGF-beta receptor signaling", "R-HSA-2173789": "TGF-beta receptor signaling activates SMADs", "R-HSA-2173791": "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "R-HSA-3000170": "Syndecan interactions", "R-HSA-3000171": "Non-integrin membrane-ECM interactions", "R-HSA-3000178": "ECM proteoglycans", "R-HSA-3304349": "Loss of Function of SMAD2/3 in Cancer", "R-HSA-3304351": "Signaling by TGF-beta Receptor Complex in Cancer", "R-HSA-3304356": "SMAD2/3 Phosphorylation Motif Mutants in Cancer", "R-HSA-3642278": "Loss of Function of TGFBR2 in Cancer", "R-HSA-3642279": "TGFBR2 MSI Frameshift Mutants in Cancer", "R-HSA-3645790": "TGFBR2 Kinase Domain Mutants in Cancer", "R-HSA-3656532": "TGFBR1 KD Mutants in Cancer", "R-HSA-3656534": "Loss of Function of TGFBR1 in Cancer", "R-HSA-3656535": "TGFBR1 LBD Mutants in Cancer", "R-HSA-5688426": "Deubiquitination", "R-HSA-5689603": "UCH proteinases", "R-HSA-8878159": "Transcriptional regulation by RUNX3", "R-HSA-8941855": "RUNX3 regulates CDKN1A transcription", "R-HSA-8941858": "Regulation of RUNX3 expression and activity", "R-HSA-8951936": "RUNX3 regulates p14-ARF", "R-HSA-9006936": "Signaling by TGFB family members", "R-HSA-9839373": "Signaling by TGFBR3", "R-HSA-9839389": "TGFBR3 regulates TGF-beta signaling", "R-HSA-1280218": "Adaptive Immune System", "R-HSA-1461973": "Defensins", "R-HSA-1462054": "Alpha-defensins", "R-HSA-162587": "HIV Life Cycle", "R-HSA-162594": "Early Phase of HIV Life Cycle", "R-HSA-162906": "HIV Infection", "R-HSA-162909": "Host Interactions of HIV factors", "R-HSA-164938": "Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters", "R-HSA-164952": "The role of Nef in HIV-1 replication and disease pathogenesis", "R-HSA-167590": "Nef Mediated CD4 Down-regulation", "R-HSA-173107": "Binding and entry of HIV virion", "R-HSA-180534": "Vpu mediated degradation of CD4", "R-HSA-202403": "TCR signaling", "R-HSA-202424": "Downstream TCR signaling", "R-HSA-202427": "Phosphorylation of CD3 and TCR zeta chains", "R-HSA-202430": "Translocation of ZAP-70 to Immunological synapse", "R-HSA-202433": "Generation of second messenger molecules", "R-HSA-388841": "Regulation of T cell activation by CD28 family", "R-HSA-389948": "Co-inhibition by PD-1", "R-HSA-449836": "Other interleukin signaling", "R-HSA-6803157": "Antimicrobial peptides", "R-HSA-9938026": "Immunoglobulin maturation", "R-HSA-9938027": "Affinity selection of immunoglobulins", "R-HSA-112314": "Neurotransmitter receptors and postsynaptic signal transmission", "R-HSA-112315": "Transmission across Chemical Synapses", "R-HSA-112316": "Neuronal System", "R-HSA-112399": "IRS-mediated signalling", "R-HSA-112412": "SOS-mediated signalling", "R-HSA-1168372": "Downstream signaling events of B Cell Receptor (BCR)", "R-HSA-1169092": "Activation of RAS in B cells", "R-HSA-1226099": "Signaling by FGFR in disease", "R-HSA-1250347": "SHC1 events in ERBB4 signaling", "R-HSA-1433557": "Signaling by SCF-KIT", "R-HSA-166520": "Signaling by NTRKs", "R-HSA-167044": "Signalling to RAS", "R-HSA-171007": "p38MAPK events", "R-HSA-186763": "Downstream signal transduction", "R-HSA-186797": "Signaling by PDGF", "R-HSA-187037": "Signaling by NTRK1 (TRKA)", "R-HSA-187687": "Signalling to ERKs", "R-HSA-190236": "Signaling by FGFR", "R-HSA-195721": "Signaling by WNT", "R-HSA-210993": "Tie2 Signaling", "R-HSA-2172127": "DAP12 interactions", "R-HSA-2424491": "DAP12 signaling", "R-HSA-2454202": "Fc epsilon receptor (FCERI) signaling", "R-HSA-2871796": "FCERI mediated MAPK activation", "R-HSA-375165": "NCAM signaling for neurite out-growth", "R-HSA-3858494": "Beta-catenin independent WNT signaling", "R-HSA-4086398": "Ca2+ pathway", "R-HSA-438064": "Post NMDA receptor activation events", "R-HSA-442742": "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling", "R-HSA-442755": "Activation of NMDA receptors and postsynaptic events", "R-HSA-442982": "Ras activation upon Ca2+ influx through NMDA receptor", "R-HSA-5621481": "C-type lectin receptors (CLRs)", "R-HSA-5621575": "CD209 (DC-SIGN) signaling", "R-HSA-5654687": "Downstream signaling of activated FGFR1", "R-HSA-5654688": "SHC-mediated cascade:FGFR1", "R-HSA-5654693": "FRS-mediated FGFR1 signaling", "R-HSA-5654696": "Downstream signaling of activated FGFR2", "R-HSA-5654699": "SHC-mediated cascade:FGFR2", "R-HSA-5654700": "FRS-mediated FGFR2 signaling", "R-HSA-5654704": "SHC-mediated cascade:FGFR3", "R-HSA-5654706": "FRS-mediated FGFR3 signaling", "R-HSA-5654708": "Downstream signaling of activated FGFR3", "R-HSA-5654712": "FRS-mediated FGFR4 signaling", "R-HSA-5654716": "Downstream signaling of activated FGFR4", "R-HSA-5654719": "SHC-mediated cascade:FGFR4", "R-HSA-5654736": "Signaling by FGFR1", "R-HSA-5654738": "Signaling by FGFR2", "R-HSA-5654741": "Signaling by FGFR3", "R-HSA-5654743": "Signaling by FGFR4", "R-HSA-5655253": "Signaling by FGFR2 in disease", "R-HSA-5655291": "Signaling by FGFR4 in disease", "R-HSA-5655302": "Signaling by FGFR1 in disease", "R-HSA-5655332": "Signaling by FGFR3 in disease", "R-HSA-5658442": "Regulation of RAS by GAPs", "R-HSA-5673000": "RAF activation", "R-HSA-5674135": "MAP2K and MAPK activation", "R-HSA-5675221": "Negative regulation of MAPK pathway", "R-HSA-6802946": "Signaling by moderate kinase activity BRAF mutants", "R-HSA-6802948": "Signaling by high-kinase activity BRAF mutants", "R-HSA-6802949": "Signaling by RAS mutants", "R-HSA-6802952": "Signaling by BRAF and RAF1 fusions", "R-HSA-6802953": "RAS signaling downstream of NF1 loss-of-function variants", "R-HSA-6802955": "Paradoxical activation of RAF signaling by kinase inactive BRAF", "R-HSA-6802957": "Oncogenic MAPK signaling", "R-HSA-6806834": "Signaling by MET", "R-HSA-8849471": "PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases", "R-HSA-8851805": "MET activates RAS signaling", "R-HSA-9006115": "Signaling by NTRK2 (TRKB)", "R-HSA-9006335": "Signaling by Erythropoietin", "R-HSA-9026519": "Activated NTRK2 signals through RAS", "R-HSA-9027284": "Erythropoietin activates RAS", "R-HSA-9028731": "Activated NTRK2 signals through FRS2 and FRS3", "R-HSA-9034015": "Signaling by NTRK3 (TRKC)", "R-HSA-9034864": "Activated NTRK3 signals through RAS", "R-HSA-9607240": "FLT3 Signaling", "R-HSA-9634285": "Constitutive Signaling by Overexpressed ERBB2", "R-HSA-9634635": "Estrogen-stimulated signaling through PRKCZ", "R-HSA-9648002": "RAS processing", "R-HSA-9649913": "RAS GTPase cycle mutants", "R-HSA-9649948": "Signaling downstream of RAS mutants", "R-HSA-9656223": "Signaling by RAF1 mutants", "R-HSA-9669938": "Signaling by KIT in disease", "R-HSA-9670439": "Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants", "R-HSA-9671555": "Signaling by PDGFR in disease", "R-HSA-9673767": "Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants", "R-HSA-9673770": "Signaling by PDGFRA extracellular domain mutants", "R-HSA-9674555": "Signaling by CSF3 (G-CSF)", "R-HSA-9680350": "Signaling by CSF1 (M-CSF) in myeloid cells", "R-HSA-9682385": "FLT3 signaling in disease", "R-HSA-9703465": "Signaling by FLT3 fusion proteins", "R-HSA-9703648": "Signaling by FLT3 ITD and TKD mutants", "R-HSA-9753510": "Signaling by RAS GAP mutants", "R-HSA-9753512": "Signaling by RAS GTPase mutants", "R-HSA-983705": "Signaling by the B Cell Receptor (BCR)", "R-HSA-109581": "Apoptosis", "R-HSA-109606": "Intrinsic Pathway for Apoptosis", "R-HSA-111448": "Activation of NOXA and translocation to mitochondria", "R-HSA-114452": "Activation of BH3-only proteins", "R-HSA-1169410": "Antimicrobial mechanism of IFN-stimulated genes", "R-HSA-139915": "Activation of PUMA and translocation to mitochondria", "R-HSA-1640170": "Cell Cycle", "R-HSA-166016": "Toll Like Receptor 4 (TLR4) Cascade", "R-HSA-166058": "MyD88:MAL(TIRAP) cascade initiated on plasma membrane", "R-HSA-166166": "MyD88-independent TLR4 cascade ", "R-HSA-168138": "Toll Like Receptor 9 (TLR9) Cascade", "R-HSA-168142": "Toll Like Receptor 10 (TLR10) Cascade", "R-HSA-168164": "Toll Like Receptor 3 (TLR3) Cascade", "R-HSA-168176": "Toll Like Receptor 5 (TLR5) Cascade", "R-HSA-168179": "Toll Like Receptor TLR1:TLR2 Cascade", "R-HSA-168181": "Toll Like Receptor 7/8 (TLR7/8) Cascade", "R-HSA-168188": "Toll Like Receptor TLR6:TLR2 Cascade", "R-HSA-168898": "Toll-like Receptor Cascades", "R-HSA-181438": "Toll Like Receptor 2 (TLR2) Cascade", "R-HSA-1912408": "Pre-NOTCH Transcription and Translation", "R-HSA-1912422": "Pre-NOTCH Expression and Processing", "R-HSA-2559580": "Oxidative Stress Induced Senescence", "R-HSA-2559584": "Formation of Senescence-Associated Heterochromatin Foci (SAHF)", "R-HSA-2559585": "Oncogene Induced Senescence", "R-HSA-2559586": "DNA Damage/Telomere Stress Induced Senescence", "R-HSA-2990846": "SUMOylation", "R-HSA-3108232": "SUMO E3 ligases SUMOylate target proteins", "R-HSA-3232118": "SUMOylation of transcription factors", "R-HSA-349425": "Autodegradation of the E3 ubiquitin ligase COP1", "R-HSA-3700989": "Transcriptional Regulation by TP53", "R-HSA-390466": "Chaperonin-mediated protein folding", "R-HSA-390471": "Association of TriC/CCT with target proteins during biosynthesis", "R-HSA-391251": "Protein folding", "R-HSA-445989": "TAK1-dependent IKK and NF-kappa-B activation  ", "R-HSA-446652": "Interleukin-1 family signaling", "R-HSA-453274": "Mitotic G2-G2/M phases", "R-HSA-5218859": "Regulated Necrosis", "R-HSA-5357801": "Programmed Cell Death", "R-HSA-5620971": "Pyroptosis", "R-HSA-5628897": "TP53 Regulates Metabolic Genes", "R-HSA-5633007": "Regulation of TP53 Activity", "R-HSA-5633008": "TP53 Regulates Transcription of Cell Death Genes", "R-HSA-5689880": "Ub-specific processing proteases", "R-HSA-5689896": "Ovarian tumor domain proteases", "R-HSA-5693532": "DNA Double-Strand Break Repair", "R-HSA-5693565": "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks", "R-HSA-5693606": "DNA Double Strand Break Response", "R-HSA-6791312": "TP53 Regulates Transcription of Cell Cycle Genes", "R-HSA-6796648": "TP53 Regulates Transcription of DNA Repair Genes", "R-HSA-6803204": "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "R-HSA-6803205": "TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain", "R-HSA-6803207": "TP53 Regulates Transcription of Caspase Activators and Caspases", "R-HSA-6803211": "TP53 Regulates Transcription of Death Receptors and Ligands", "R-HSA-6804114": "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest", "R-HSA-6804115": "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain", "R-HSA-6804116": "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest", "R-HSA-6804754": "Regulation of TP53 Expression", "R-HSA-6804756": "Regulation of TP53 Activity through Phosphorylation", "R-HSA-6804757": "Regulation of TP53 Degradation", "R-HSA-6804758": "Regulation of TP53 Activity through Acetylation", "R-HSA-6804759": "Regulation of TP53 Activity through Association with Co-factors", "R-HSA-6804760": "Regulation of TP53 Activity through Methylation", "R-HSA-6806003": "Regulation of TP53 Expression and Degradation", "R-HSA-6807070": "PTEN Regulation", "R-HSA-6811555": "PI5P Regulates TP53 Acetylation", "R-HSA-69275": "G2/M Transition", "R-HSA-69278": "Cell Cycle, Mitotic", "R-HSA-69473": "G2/M DNA damage checkpoint", "R-HSA-69481": "G2/M Checkpoints", "R-HSA-69541": "Stabilization of p53", "R-HSA-69560": "Transcriptional activation of p53 responsive genes  ", "R-HSA-69563": "p53-Dependent G1 DNA Damage Response", "R-HSA-69580": "p53-Dependent G1/S DNA damage checkpoint", "R-HSA-69615": "G1/S DNA Damage Checkpoints", "R-HSA-69620": "Cell Cycle Checkpoints", "R-HSA-69895": "Transcriptional  activation of  cell cycle inhibitor p21 ", "R-HSA-70635": "Urea cycle", "R-HSA-71291": "Metabolism of amino acids and derivatives", "R-HSA-73894": "DNA Repair", "R-HSA-8852276": "The role of GTSE1 in G2/M progression after G2 checkpoint", "R-HSA-8943724": "Regulation of PTEN gene transcription", "R-HSA-9020702": "Interleukin-1 signaling", "R-HSA-913531": "Interferon Signaling", "R-HSA-937061": "TRIF (TICAM1)-mediated TLR4 signaling ", "R-HSA-9645723": "Diseases of programmed cell death", "R-HSA-9700206": "Signaling by ALK in cancer", "R-HSA-9723905": "Loss of function of TP53 in cancer due to loss of tetramerization ability", "R-HSA-9723907": "Loss of Function of TP53 in Cancer", "R-HSA-9725370": "Signaling by ALK fusions and activated point mutants", "R-HSA-9734009": "Defective Intrinsic Pathway for Apoptosis", "R-HSA-975138": "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation", "R-HSA-975155": "MyD88 dependent cascade initiated on endosome", "R-HSA-9758274": "Regulation of NF-kappa B signaling", "R-HSA-975871": "MyD88 cascade initiated on plasma membrane", "R-HSA-9816359": "Maternal to zygotic transition (MZT)", "R-HSA-9819196": "Zygotic genome activation (ZGA)", "R-HSA-983231": "Factors involved in megakaryocyte development and platelet production", "R-HSA-9833482": "PKR-mediated signaling", "R-HSA-9938024": "Somatic hypermutation of immunoglobulin genes", "R-HSA-9988426": "Negative transcriptional regulation of urea cycle enzymes", "R-HSA-1442490": "Collagen degradation", "R-HSA-1474228": "Degradation of the extracellular matrix", "R-HSA-1474290": "Collagen formation", "R-HSA-1592389": "Activation of Matrix Metalloproteinases", "R-HSA-2022090": "Assembly of collagen fibrils and other multimeric structures", "R-HSA-2682334": "EPH-Ephrin signaling", "R-HSA-3928665": "EPH-ephrin mediated repulsion of cells", "R-HSA-6798695": "Neutrophil degranulation", "R-HSA-9839923": "Dengue Virus Infection", "R-HSA-9918481": "Dengue Virus-Host Interactions", "R-HSA-204005": "COPII-mediated vesicle transport", "R-HSA-5694530": "Cargo concentration in the ER", "R-HSA-159740": "Gamma-carboxylation of protein precursors", "R-HSA-159763": "Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus", "R-HSA-159782": "Removal of aminoterminal propeptides from gamma-carboxylated proteins", "R-HSA-159854": "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins", "R-HSA-163841": "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "R-HSA-373076": "Class A/1 (Rhodopsin-like receptors)", "R-HSA-375276": "Peptide ligand-binding receptors", "R-HSA-456926": "Thrombin signalling through proteinase activated receptors (PARs)", "R-HSA-500792": "GPCR ligand binding", "R-HSA-5260271": "Diseases of Immune System", "R-HSA-76009": "Platelet Aggregation (Plug Formation)", "R-HSA-9657688": "Defective factor XII causes hereditary angioedema", "R-HSA-9662001": "Defective factor VIII causes hemophilia A", "R-HSA-9671793": "Diseases of hemostasis", "R-HSA-9672391": "Defective F8 cleavage by thrombin", "R-HSA-9769726": "Defects of Coagulation cascade", "R-HSA-9769733": "Fibrin formation", "R-HSA-9769735": "Initiation of coagulation cascade", "R-HSA-9769739": "Regulation of clotting cascade", "R-HSA-9769740": "Coagulation pathway", "R-HSA-9769743": "Amplification and propagation of coagulation cascade", "R-HSA-977606": "Regulation of Complement cascade", "R-HSA-9946127": "Defects of contact activation system and kallikrein-kinin system ", "R-HSA-173736": "Alternative complement activation", "R-HSA-174577": "Activation of C3 and C5", "R-HSA-198933": "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell", "R-HSA-418594": "G alpha (i) signalling events", "R-HSA-9660826": "Purinergic signaling in leishmaniasis infection", "R-HSA-9664424": "Cell recruitment (pro-inflammatory response)", "R-HSA-2586552": "Signaling by Leptin", "R-HSA-381771": "Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)", "R-HSA-400508": "Incretin synthesis, secretion, and inactivation", "R-HSA-448706": "Interleukin-1 processing", "R-HSA-5607764": "CLEC7A (Dectin-1) signaling", "R-HSA-5660668": "CLEC7A/inflammasome pathway", "R-HSA-9686114": "Non-canonical inflammasome activation", "R-HSA-9960519": "CASP4-mediated substrate cleavage", "R-HSA-9960525": "CASP5-mediated substrate cleavage", "R-HSA-380108": "Chemokine receptors bind chemokines", "R-HSA-380994": "ATF4 activates genes in response to endoplasmic reticulum  stress", "R-HSA-381042": "PERK regulates gene expression", "R-HSA-381119": "Unfolded Protein Response (UPR)", "R-HSA-8963896": "HDL assembly", "R-HSA-9855719": "Regulation of FXIIa and plasma kallikrein activity", "R-HSA-9970672": "FXIIa activates plasma kallikrein-kinin system", "R-HSA-1630316": "Glycosaminoglycan metabolism", "R-HSA-1638074": "Keratan sulfate/keratin metabolism", "R-HSA-2022854": "Keratan sulfate biosynthesis", "R-HSA-2022857": "Keratan sulfate degradation", "R-HSA-3560782": "Diseases associated with glycosaminoglycan metabolism", "R-HSA-3656225": "Defective CHST6 causes MCDC1", "R-HSA-3656243": "Defective ST3GAL3 causes MCT12 and EIEE15", "R-HSA-3656244": "Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)", "R-HSA-3781865": "Diseases of glycosylation", "R-HSA-5668914": "Diseases of metabolism", "R-HSA-71387": "Metabolism of carbohydrates and carbohydrate derivatives", "R-HSA-2022377": "Metabolism of Angiotensinogen to Angiotensins", "R-HSA-3906995": "Diseases associated with O-glycosylation of proteins", "R-HSA-5083635": "Defective B3GALTL causes PpS", "R-HSA-5173105": "O-linked glycosylation", "R-HSA-5173214": "O-glycosylation of TSR domain-containing proteins", "R-HSA-75892": "Platelet Adhesion to exposed collagen", "R-HSA-9823587": "Defects of platelet adhesion to exposed collagen", "R-HSA-9845619": "Enhanced cleavage of VWF variant by ADAMTS13", "R-HSA-9845621": "Defective VWF cleavage by ADAMTS13 variant", "R-HSA-1169091": "Activation of NF-kappaB in B cells", "R-HSA-1234176": "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "R-HSA-1236974": "ER-Phagosome pathway", "R-HSA-1236975": "Antigen processing-Cross presentation", "R-HSA-1236978": "Cross-presentation of soluble exogenous antigens (endosomes)", "R-HSA-169911": "Regulation of Apoptosis", "R-HSA-174084": "Autodegradation of Cdh1 by Cdh1:APC/C", "R-HSA-174113": "SCF-beta-TrCP mediated degradation of Emi1", "R-HSA-174143": "APC/C-mediated degradation of cell cycle proteins", "R-HSA-174154": "APC/C:Cdc20 mediated degradation of Securin", "R-HSA-174178": "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "R-HSA-174184": "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "R-HSA-176408": "Regulation of APC/C activators between G1/S and early anaphase", "R-HSA-176409": "APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-176814": "Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins", "R-HSA-179419": "APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint", "R-HSA-180585": "Vif-mediated degradation of APOBEC3G", "R-HSA-187577": "SCF(Skp2)-mediated degradation of p27/p21", "R-HSA-195253": "Degradation of beta-catenin by the destruction complex", "R-HSA-201681": "TCF dependent signaling in response to WNT", "R-HSA-211733": "Regulation of activated PAK-2p34 by proteasome mediated degradation", "R-HSA-2467813": "Separation of Sister Chromatids", "R-HSA-2555396": "Mitotic Metaphase and Anaphase", "R-HSA-2871837": "FCERI mediated NF-kB activation", "R-HSA-350562": "Regulation of ornithine decarboxylase (ODC)", "R-HSA-351202": "Metabolism of polyamines", "R-HSA-376176": "Signaling by ROBO receptors", "R-HSA-382556": "ABC-family protein mediated transport", "R-HSA-4086400": "PCP/CE pathway", "R-HSA-450408": "AUF1 (hnRNP D0) binds and destabilizes mRNA", "R-HSA-450531": "Regulation of mRNA stability by proteins that bind AU-rich elements", "R-HSA-453276": "Regulation of mitotic cell cycle", "R-HSA-453279": "Mitotic G1 phase and G1/S transition", "R-HSA-4608870": "Asymmetric localization of PCP proteins", "R-HSA-4641257": "Degradation of AXIN", "R-HSA-4641258": "Degradation of DVL", "R-HSA-5358346": "Hedgehog ligand biogenesis", "R-HSA-5358351": "Signaling by Hedgehog", "R-HSA-5362768": "Hh mutants are degraded by ERAD", "R-HSA-5387390": "Hh mutants abrogate ligand secretion", "R-HSA-5607761": "Dectin-1 mediated noncanonical NF-kB signaling", "R-HSA-5610780": "Degradation of GLI1 by the proteasome", "R-HSA-5610783": "Degradation of GLI2 by the proteasome", "R-HSA-5610785": "GLI3 is processed to GLI3R by the proteasome", "R-HSA-5610787": "Hedgehog 'off' state", "R-HSA-5619084": "ABC transporter disorders", "R-HSA-5619115": "Disorders of transmembrane transporters", "R-HSA-5632684": "Hedgehog 'on' state", "R-HSA-5676590": "NIK-->noncanonical NF-kB signaling", "R-HSA-5678895": "Defective CFTR causes cystic fibrosis", "R-HSA-5687128": "MAPK6/MAPK4 signaling", "R-HSA-68867": "Assembly of the pre-replicative complex", "R-HSA-68882": "Mitotic Anaphase", "R-HSA-68886": "M Phase", "R-HSA-68949": "Orc1 removal from chromatin", "R-HSA-69002": "DNA Replication Pre-Initiation", "R-HSA-69017": "CDK-mediated phosphorylation and removal of Cdc6", "R-HSA-69052": "Switching of origins to a post-replicative state", "R-HSA-69202": "Cyclin E associated events during G1/S transition ", "R-HSA-69206": "G1/S Transition", "R-HSA-69239": "Synthesis of DNA", "R-HSA-69242": "S Phase", "R-HSA-69306": "DNA Replication", "R-HSA-69601": "Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A", "R-HSA-69613": "p53-Independent G1/S DNA Damage Checkpoint", "R-HSA-69656": "Cyclin A:Cdk2-associated events at S phase entry", "R-HSA-72766": "Translation", "R-HSA-75815": "Ubiquitin-dependent degradation of Cyclin D", "R-HSA-8854050": "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "R-HSA-8878166": "Transcriptional regulation by RUNX2", "R-HSA-8878171": "Transcriptional regulation by RUNX1", "R-HSA-8939236": "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "R-HSA-8939902": "Regulation of RUNX2 expression and activity", "R-HSA-8948751": "Regulation of PTEN stability and activity", "R-HSA-8951664": "Neddylation", "R-HSA-8953854": "Metabolism of RNA", "R-HSA-9010553": "Regulation of expression of SLITs and ROBOs", "R-HSA-9013694": "Signaling by NOTCH4", "R-HSA-9604323": "Negative regulation of NOTCH4 signaling", "R-HSA-9755511": "KEAP1-NFE2L2 pathway", "R-HSA-9758941": "Gastrulation", "R-HSA-9759194": "Nuclear events mediated by NFE2L2", "R-HSA-9759476": "Regulation of Homotypic Cell-Cell Adhesion", "R-HSA-9762114": "GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2", "R-HSA-9764265": "Regulation of CDH1 Expression and Function", "R-HSA-9764274": "Regulation of Expression and Function of Type I Classical Cadherins", "R-HSA-9764561": "Regulation of CDH1 Function", "R-HSA-9766229": "Degradation of CDH1", "R-HSA-9793380": "Formation of paraxial mesoderm", "R-HSA-9824272": "Somitogenesis", "R-HSA-983168": "Antigen processing: Ubiquitination & Proteasome degradation", "R-HSA-983169": "Class I MHC mediated antigen processing & presentation", "R-HSA-9907900": "Proteasome assembly", "R-HSA-9909396": "Circadian clock", "R-HSA-9909615": "Regulation of PD-L1(CD274) Post-translational modification", "R-HSA-9909648": "Regulation of PD-L1(CD274) expression", "R-HSA-9929356": "GSK3B-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9929491": "SPOP-mediated proteasomal degradation of PD-L1(CD274)", "R-HSA-9931269": "AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)", "R-HSA-9932298": "Degradation of CRY and PER proteins", "R-HSA-9948299": "Ribosome-associated quality control", "R-HSA-9954709": "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "R-HSA-9974237": "Negative Regulation of DNA Double Strand Break Response", "R-HSA-168928": "DDX58/IFIH1-mediated induction of interferon-alpha/beta", "R-HSA-879415": "Advanced glycosylation endproduct receptor signaling", "R-HSA-933542": "TRAF6 mediated NF-kB activation", "R-HSA-1638091": "Heparan sulfate/heparin (HS-GAG) metabolism", "R-HSA-1971475": "Glycosaminoglycan-protein linkage region biosynthesis", "R-HSA-2022928": "HS-GAG biosynthesis", "R-HSA-2024096": "HS-GAG degradation", "R-HSA-216083": "Integrin cell surface interactions", "R-HSA-3560783": "Defective B4GALT7 causes EDS, progeroid type", "R-HSA-3560801": "Defective B3GAT3 causes JDSSDHD", "R-HSA-3656237": "Defective EXT2 causes exostoses 2", "R-HSA-3656253": "Defective EXT1 causes exostoses 1, TRPS2 and CHDS", "R-HSA-419037": "NCAM1 interactions", "R-HSA-4420332": "Defective B3GALT6 causes EDSP2 and SEMDJL1", "R-HSA-9694516": "SARS-CoV-2 Infection", "R-HSA-9694614": "Attachment and Entry", "R-HSA-9772572": "Early SARS-CoV-2 Infection Events", "R-HSA-9833110": "RSV-host interactions", "R-HSA-9913351": "Formation of the dystrophin-glycoprotein complex (DGC)", "R-HSA-9918485": "Dengue Virus Attachment and Entry", "R-HSA-211859": "Biological oxidations", "R-HSA-211945": "Phase I - Functionalization of compounds", "R-HSA-5362517": "Signaling by Retinoic Acid", "R-HSA-5365859": "RA biosynthesis pathway", "R-HSA-5652084": "Fructose metabolism", "R-HSA-70350": "Fructose catabolism", "R-HSA-71384": "Ethanol oxidation", "R-HSA-9927418": "Developmental Lineage of Mammary Gland Luminal Epithelial Cells", "R-HSA-9938206": "Developmental Lineage of Mammary Stem Cells", "R-HSA-397014": "Muscle contraction", "R-HSA-445355": "Smooth Muscle Contraction", "R-HSA-447115": "Interleukin-12 family signaling", "R-HSA-75205": "Dissolution of Fibrin Clot", "R-HSA-8950505": "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation", "R-HSA-9020591": "Interleukin-12 signaling", "R-HSA-9820448": "Developmental Cell Lineages of the Exocrine Pancreas", "R-HSA-9855142": "Cellular responses to mechanical stimuli", "R-HSA-9860927": "Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells", "R-HSA-9860931": "Response of endothelial cells to shear stress", "R-HSA-9925563": "Developmental Lineage of Pancreatic Ductal Cells", "R-HSA-168643": "Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways", "R-HSA-199992": "trans-Golgi Network Vesicle Budding", "R-HSA-432720": "Lysosome Vesicle Biogenesis", "R-HSA-444473": "Formyl peptide receptors bind formyl peptides and many other ligands", "R-HSA-622312": "Inflammasomes", "R-HSA-844456": "The NLRP3 inflammasome", "R-HSA-8862803": "Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models", "R-HSA-8863678": "Neurodegenerative Diseases", "R-HSA-9609507": "Protein localization", "R-HSA-9609523": "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane", "R-HSA-9837999": "Mitochondrial protein degradation", "R-HSA-9936686": "Aggregated \u03b2-amyloid interacts with fibrinogen", "R-HSA-9936900": "Aggregated \u03b2-amyloid induces FXII autocatalysis", "R-HSA-111465": "Apoptotic cleavage of cellular proteins", "R-HSA-168638": "NOD1/2 Signaling Pathway", "R-HSA-168927": "TICAM1, RIP1-mediated IKK complex recruitment", "R-HSA-5213460": "RIPK1-mediated regulated necrosis", "R-HSA-5675482": "Regulation of necroptotic cell death", "R-HSA-5676594": "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway", "R-HSA-75153": "Apoptotic execution phase", "R-HSA-937041": "IKK complex recruitment mediated by RIP1", "R-HSA-1237044": "Erythrocytes take up carbon dioxide and release oxygen", "R-HSA-1247673": "Erythrocytes take up oxygen and release carbon dioxide", "R-HSA-1475029": "Reversible hydration of carbon dioxide", "R-HSA-1480926": "O2/CO2 exchange in erythrocytes", "R-HSA-8877330": "RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)", "R-HSA-8931987": "RUNX1 regulates estrogen receptor mediated transcription", "R-HSA-8934593": "Regulation of RUNX1 Expression and Activity", "R-HSA-8935964": "RUNX1 regulates expression of components of tight junctions", "R-HSA-8936459": "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function", "R-HSA-8939242": "RUNX1 regulates transcription of genes involved in differentiation of keratinocytes", "R-HSA-8939243": "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known", "R-HSA-8939245": "RUNX1 regulates transcription of genes involved in BCR signaling", "R-HSA-8939246": "RUNX1 regulates transcription of genes involved in differentiation of myeloid cells", "R-HSA-8939247": "RUNX1 regulates transcription of genes involved in interleukin signaling", "R-HSA-8939256": "RUNX1 regulates transcription of genes involved in WNT signaling", "R-HSA-8940973": "RUNX2 regulates osteoblast differentiation", "R-HSA-8941284": "RUNX2 regulates chondrocyte maturation", "R-HSA-8941326": "RUNX2 regulates bone development", "R-HSA-8941332": "RUNX2 regulates genes involved in cell migration", "R-HSA-8941333": "RUNX2 regulates genes involved in differentiation of myeloid cells", "R-HSA-8949275": "RUNX3 Regulates Immune Response and Cell Migration", "R-HSA-8951911": "RUNX3 regulates RUNX1-mediated transcription", "R-HSA-9018519": "Estrogen-dependent gene expression", "R-HSA-9616222": "Transcriptional regulation of granulopoiesis", "R-HSA-5669034": "TNFs bind their physiological receptors", "R-HSA-6788467": "IL-6-type cytokine receptor ligand interactions", "R-HSA-71336": "Pentose phosphate pathway", "R-HSA-109704": "PI3K Cascade", "R-HSA-1839122": "Signaling by activated point mutants of FGFR1", "R-HSA-1839124": "FGFR1 mutant receptor activation", "R-HSA-1839126": "FGFR2 mutant receptor activation", "R-HSA-1839130": "Signaling by activated point mutants of FGFR3", "R-HSA-190239": "FGFR3 ligand binding and activation", "R-HSA-190241": "FGFR2 ligand binding and activation", "R-HSA-190242": "FGFR1 ligand binding and activation", "R-HSA-190322": "FGFR4 ligand binding and activation", "R-HSA-190370": "FGFR1b ligand binding and activation", "R-HSA-190371": "FGFR3b ligand binding and activation", "R-HSA-190372": "FGFR3c ligand binding and activation", "R-HSA-190373": "FGFR1c ligand binding and activation", "R-HSA-190375": "FGFR2c ligand binding and activation", "R-HSA-190377": "FGFR2b ligand binding and activation", "R-HSA-2033514": "FGFR3 mutant receptor activation", "R-HSA-2033519": "Activated point mutants of FGFR2", "R-HSA-5654219": "Phospholipase C-mediated cascade: FGFR1", "R-HSA-5654221": "Phospholipase C-mediated cascade; FGFR2", "R-HSA-5654227": "Phospholipase C-mediated cascade; FGFR3", "R-HSA-5654228": "Phospholipase C-mediated cascade; FGFR4", "R-HSA-5654689": "PI-3K cascade:FGFR1", "R-HSA-5654695": "PI-3K cascade:FGFR2", "R-HSA-5654710": "PI-3K cascade:FGFR3", "R-HSA-5654720": "PI-3K cascade:FGFR4", "R-HSA-5654726": "Negative regulation of FGFR1 signaling", "R-HSA-5654727": "Negative regulation of FGFR2 signaling", "R-HSA-5654732": "Negative regulation of FGFR3 signaling", "R-HSA-5654733": "Negative regulation of FGFR4 signaling", "R-HSA-8851708": "Signaling by FGFR2 IIIa TM", "R-HSA-114604": "GPVI-mediated activation cascade", "R-HSA-1433559": "Regulation of KIT signaling", "R-HSA-164944": "Nef and signal transduction", "R-HSA-2029480": "Fcgamma receptor (FCGR) dependent phagocytosis", "R-HSA-2029481": "FCGR activation", "R-HSA-210990": "PECAM1 interactions", "R-HSA-2730905": "Role of LAT2/NTAL/LAB on calcium mobilization", "R-HSA-373752": "Netrin-1 signaling", "R-HSA-373753": "Nephrin family interactions", "R-HSA-373755": "Semaphorin interactions", "R-HSA-389356": "Co-stimulation by CD28", "R-HSA-389357": "CD28 dependent PI3K/Akt signaling", "R-HSA-389359": "CD28 dependent Vav1 pathway", "R-HSA-389513": "Co-inhibition by CTLA4", "R-HSA-3928662": "EPHB-mediated forward signaling", "R-HSA-3928663": "EPHA-mediated growth cone collapse", "R-HSA-3928664": "Ephrin signaling", "R-HSA-399954": "Sema3A PAK dependent Axon repulsion", "R-HSA-399955": "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "R-HSA-399956": "CRMPs in Sema3A signaling", "R-HSA-418885": "DCC mediated attractive signaling", "R-HSA-512988": "Interleukin-3, Interleukin-5 and GM-CSF signaling", "R-HSA-5621480": "Dectin-2 family", "R-HSA-8866376": "Reelin signalling pathway", "R-HSA-9032500": "Activated NTRK2 signals through FYN", "R-HSA-9032759": "NTRK2 activates RAC1", "R-HSA-912631": "Regulation of signaling by CBL", "R-HSA-9664323": "FCGR3A-mediated IL10 synthesis", "R-HSA-9664407": "Parasite infection", "R-HSA-9664417": "Leishmania phagocytosis", "R-HSA-9664422": "FCGR3A-mediated phagocytosis", "R-HSA-9706374": "FLT3 signaling through SRC family kinases", "R-HSA-983695": "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers", "R-HSA-9856530": "High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells", "R-HSA-9912633": "Antigen processing: Ub, ATP-independent proteasomal degradation", "R-HSA-1660662": "Glycosphingolipid metabolism", "R-HSA-428157": "Sphingolipid metabolism", "R-HSA-9840309": "Glycosphingolipid biosynthesis", "R-HSA-1482839": "Acyl chain remodelling of PE", "R-HSA-1483206": "Glycerophospholipid biosynthesis", "R-HSA-1483257": "Phospholipid metabolism", "R-HSA-194315": "Signaling by Rho GTPases", "R-HSA-195258": "RHO GTPase Effectors", "R-HSA-2029482": "Regulation of actin dynamics for phagocytic cup formation", "R-HSA-212165": "Epigenetic regulation of gene expression", "R-HSA-428890": "Role of ABL in ROBO-SLIT signaling", "R-HSA-525793": "Myogenesis", "R-HSA-5663213": "RHO GTPases Activate WASPs and WAVEs", "R-HSA-5685938": "HDR through Single Strand Annealing (SSA)", "R-HSA-5693538": "Homology Directed Repair", "R-HSA-5693567": "HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)", "R-HSA-69231": "Cyclin D associated events in G1", "R-HSA-69236": "G1 Phase", "R-HSA-9716542": "Signaling by Rho GTPases, Miro GTPases and RHOBTB3", "R-HSA-9818564": "Epigenetic regulation of gene expression by MLL3 and MLL4 complexes", "R-HSA-9841922": "MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis", "R-HSA-9851695": "Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes", "R-HSA-9917777": "Epigenetic regulation by WDR5-containing histone modifying complexes", "R-HSA-110328": "Recognition and association of DNA glycosylase with site containing an affected pyrimidine", "R-HSA-110329": "Cleavage of the damaged pyrimidine ", "R-HSA-110330": "Recognition and association of DNA glycosylase with site containing an affected purine", "R-HSA-110331": "Cleavage of the damaged purine", "R-HSA-1221632": "Meiotic synapsis", "R-HSA-1474165": "Reproduction", "R-HSA-1500620": "Meiosis", "R-HSA-157579": "Telomere Maintenance", "R-HSA-171306": "Packaging Of Telomere Ends", "R-HSA-171319": "Telomere Extension By Telomerase", "R-HSA-174411": "Polymerase switching on the C-strand of the telomere", "R-HSA-174414": "Processive synthesis on the C-strand of the telomere", "R-HSA-174417": "Telomere C-strand (Lagging Strand) Synthesis", "R-HSA-174430": "Telomere C-strand synthesis initiation", "R-HSA-174437": "Removal of the Flap Intermediate from the C-strand", "R-HSA-180786": "Extension of Telomeres", "R-HSA-73884": "Base Excision Repair", "R-HSA-73886": "Chromosome Maintenance", "R-HSA-73927": "Depurination", "R-HSA-73928": "Depyrimidination", "R-HSA-73929": "Base-Excision Repair, AP Site Formation", "R-HSA-9670095": "Inhibition of DNA recombination at telomere", "R-HSA-1445148": "Translocation of SLC2A4 (GLUT4) to the plasma membrane", "R-HSA-157858": "Gap junction trafficking and regulation", "R-HSA-190828": "Gap junction trafficking", "R-HSA-190873": "Gap junction degradation", "R-HSA-196025": "Formation of annular gap junctions", "R-HSA-3214847": "HATs acetylate histones", "R-HSA-3247509": "Chromatin modifying enzymes", "R-HSA-389957": "Prefoldin mediated transfer of substrate  to CCT/TriC", "R-HSA-389958": "Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding", "R-HSA-390450": "Folding of actin by CCT/TriC", "R-HSA-428359": "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA", "R-HSA-437239": "Recycling pathway of L1", "R-HSA-445095": "Interaction between L1 and Ankyrins", "R-HSA-446353": "Cell-extracellular matrix interactions", "R-HSA-4839726": "Chromatin organization", "R-HSA-5250913": "Positive epigenetic regulation of rRNA expression", "R-HSA-5250924": "B-WICH complex positively regulates rRNA expression", "R-HSA-5626467": "RHO GTPases activate IQGAPs", "R-HSA-5663220": "RHO GTPases Activate Formins", "R-HSA-5696394": "DNA Damage Recognition in GG-NER", "R-HSA-5696398": "Nucleotide Excision Repair", "R-HSA-5696399": "Global Genome Nucleotide Excision Repair (GG-NER)", "R-HSA-9012999": "RHO GTPase cycle", "R-HSA-9035034": "RHOF GTPase cycle", "R-HSA-9659379": "Sensory processing of sound", "R-HSA-9662360": "Sensory processing of sound by inner hair cells of the cochlea", "R-HSA-9662361": "Sensory processing of sound by outer hair cells of the cochlea", "R-HSA-9730414": "MITF-M-regulated melanocyte development", "R-HSA-9824585": "Regulation of MITF-M-dependent genes involved in pigmentation", "R-HSA-9842860": "Regulation of endogenous retroelements", "R-HSA-9845323": "Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)", "R-HSA-9856651": "MITF-M-dependent gene expression", "R-HSA-9932444": "ATP-dependent chromatin remodelers", "R-HSA-9932451": "SWI/SNF chromatin remodelers", "R-HSA-9933937": "Formation of the canonical BAF (cBAF) complex", "R-HSA-9933939": "Formation of the polybromo-BAF (pBAF) complex", "R-HSA-9933946": "Formation of the embryonic stem cell BAF (esBAF) complex", "R-HSA-9933947": "Formation of the non-canonical BAF (ncBAF) complex", "R-HSA-9934037": "Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)", "R-HSA-9953170": "GBP-mediated host defense", "R-HSA-111885": "Opioid Signalling", "R-HSA-111931": "PKA-mediated phosphorylation of CREB", "R-HSA-111933": "Calmodulin induced events", "R-HSA-111996": "Ca-dependent events", "R-HSA-111997": "CaM pathway", "R-HSA-112040": "G-protein mediated events", "R-HSA-112043": "PLC beta mediated events", "R-HSA-1489509": "DAG and IP3 signaling", "R-HSA-163359": "Glucagon signaling in metabolic regulation", "R-HSA-163615": "PKA activation", "R-HSA-164378": "PKA activation in glucagon signalling", "R-HSA-170660": "Adenylate cyclase activating pathway", "R-HSA-170670": "Adenylate cyclase inhibitory pathway", "R-HSA-381753": "Olfactory Signaling Pathway", "R-HSA-418555": "G alpha (s) signalling events", "R-HSA-418597": "G alpha (z) signalling events", "R-HSA-432040": "Vasopressin regulates renal water homeostasis via Aquaporins", "R-HSA-445717": "Aquaporin-mediated transport", "R-HSA-9634597": "GPER1 signaling", "R-HSA-977443": "GABA receptor activation", "R-HSA-977444": "GABA B receptor activation", "R-HSA-991365": "Activation of GABAB receptors", "R-HSA-9937848": "CHD chromatin remodelers", "R-HSA-9940465": "ChAHP complex assembly", "R-HSA-9943965": "CHD3, CHD4, CHD5 subfamily", "R-HSA-417973": "Adenosine P1 receptors", "R-HSA-418038": "Nucleotide-like (purinergic) receptors", "R-HSA-375280": "Amine ligand-binding receptors", "R-HSA-390696": "Adrenoceptors", "R-HSA-416482": "G alpha (12/13) signalling events", "R-HSA-212300": "PRC2 methylates histones and DNA", "R-HSA-3214841": "PKMTs methylate histone lysines", "R-HSA-165159": "MTOR signalling", "R-HSA-203927": "MicroRNA (miRNA) biogenesis", "R-HSA-211000": "Gene Silencing by RNA", "R-HSA-426486": "Small interfering RNA (siRNA) biogenesis", "R-HSA-426496": "Post-transcriptional silencing by small RNAs", "R-HSA-5578749": "Transcriptional regulation by small RNAs", "R-HSA-8943723": "Regulation of PTEN mRNA translation", "R-HSA-8948700": "Competing endogenous RNAs (ceRNAs) regulate PTEN translation", "R-HSA-8986944": "Transcriptional Regulation by MECP2", "R-HSA-9022692": "Regulation of MECP2 expression and activity", "R-HSA-9725371": "Nuclear events stimulated by ALK signaling in cancer", "R-HSA-9759475": "Regulation of CDH11 Expression and Function", "R-HSA-9759811": "Regulation of CDH11 mRNA translation by microRNAs", "R-HSA-9764260": "Regulation of Expression and Function of Type II Classical Cadherins", "R-HSA-9764562": "Regulation of CDH1 mRNA translation by microRNAs", "R-HSA-9768759": "Regulation of NPAS4 gene expression", "R-HSA-9768778": "Regulation of NPAS4 mRNA translation", "R-HSA-9824594": "Regulation of MITF-M-dependent genes involved in apoptosis", "R-HSA-9839394": "TGFBR3 expression", "R-HSA-9909620": "Regulation of PD-L1(CD274) translation", "R-HSA-9945556": "Transcriptional regulation of multiciliogenesis", "R-HSA-9975924": "Assembly of the 9+2 motile cilia", "R-HSA-9821002": "Chromatin modifications during the maternal to zygotic transition (MZT)", "R-HSA-2565942": "Regulation of PLK1 Activity at G2/M Transition", "R-HSA-380259": "Loss of Nlp from mitotic centrosomes", "R-HSA-380270": "Recruitment of mitotic centrosome proteins and complexes", "R-HSA-380284": "Loss of proteins required for interphase microtubule organization from the centrosome", "R-HSA-380287": "Centrosome maturation", "R-HSA-380320": "Recruitment of NuMA to mitotic centrosomes", "R-HSA-5576890": "Phase 3 - rapid repolarisation", "R-HSA-5576891": "Cardiac conduction", "R-HSA-5576893": "Phase 2 - plateau phase", "R-HSA-68877": "Mitotic Prometaphase", "R-HSA-8854518": "AURKA Activation by TPX2", "R-HSA-9645460": "Alpha-protein kinase 1 signaling pathway", "R-HSA-189085": "Digestion of dietary carbohydrate", "R-HSA-8935690": "Digestion", "R-HSA-8963743": "Digestion and absorption", "R-HSA-193692": "Regulated proteolysis of p75NTR", "R-HSA-193704": "p75 NTR receptor-mediated signalling", "R-HSA-1980143": "Signaling by NOTCH1", "R-HSA-1980145": "Signaling by NOTCH2", "R-HSA-204998": "Cell death signalling via NRAGE, NRIF and NADE", "R-HSA-205043": "NRIF signals cell death from the nucleus", "R-HSA-2122948": "Activated NOTCH1 Transmits Signal to the Nucleus", "R-HSA-2644602": "Signaling by NOTCH1 PEST Domain Mutants in Cancer", "R-HSA-2644603": "Signaling by NOTCH1 in Cancer", "R-HSA-2644606": "Constitutive Signaling by NOTCH1 PEST Domain Mutants", "R-HSA-2894858": "Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer", "R-HSA-2894862": "Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants", "R-HSA-2979096": "NOTCH2 Activation and Transmission of Signal to the Nucleus", "R-HSA-9013700": "NOTCH4 Activation and Transmission of Signal to the Nucleus", "R-HSA-9017802": "Noncanonical activation of NOTCH3", "R-HSA-9839383": "TGFBR3 PTM regulation", "R-HSA-432047": "Passive transport by Aquaporins", "R-HSA-3371497": "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand", "R-HSA-383280": "Nuclear Receptor transcription pathway", "R-HSA-4090294": "SUMOylation of intracellular receptors", "R-HSA-5625740": "RHO GTPases activate PKNs", "R-HSA-5625886": "Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3", "R-HSA-3214858": "RMTs methylate histone arginines", "R-HSA-9764560": "Regulation of CDH1 Gene Transcription", "R-HSA-9764790": "Positive Regulation of CDH1 Gene Transcription", "R-HSA-3214815": "HDACs deacetylate histones", "R-HSA-427413": "NoRC negatively regulates rRNA expression", "R-HSA-5250941": "Negative epigenetic regulation of rRNA expression", "R-HSA-201722": "Formation of the beta-catenin:TCF transactivating complex", "R-HSA-3769402": "Deactivation of the beta-catenin transactivating complex", "R-HSA-5617472": "Activation of anterior HOX genes in hindbrain development during early embryogenesis", "R-HSA-5619507": "Activation of HOX genes during differentiation", "R-HSA-9675151": "Disorders of Developmental Biology", "R-HSA-9772755": "Formation of WDR5-containing histone-modifying complexes", "R-HSA-9909649": "Regulation of PD-L1(CD274) transcription", "R-HSA-9944971": "Loss of Function of KMT2D in Kabuki Syndrome", "R-HSA-9944997": "Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome", "R-HSA-9976102": "Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells)", "R-HSA-9843940": "Regulation of endogenous retroelements by KRAB-ZFP proteins", "R-HSA-9843970": "Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex", "R-HSA-1632852": "Macroautophagy", "R-HSA-3371453": "Regulation of HSF1-mediated heat shock response", "R-HSA-3371556": "Cellular response to heat stress", "R-HSA-5685942": "HDR through Homologous Recombination (HRR)", "R-HSA-5693537": "Resolution of D-Loop Structures", "R-HSA-5693548": "Sensing of DNA Double Strand Breaks", "R-HSA-5693554": "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)", "R-HSA-5693568": "Resolution of D-loop Structures through Holliday Junction Intermediates", "R-HSA-5693571": "Nonhomologous End-Joining (NHEJ)", "R-HSA-5693579": "Homologous DNA Pairing and Strand Exchange", "R-HSA-5693607": "Processing of DNA double-strand break ends", "R-HSA-5693616": "Presynaptic phase of homologous DNA pairing and strand exchange", "R-HSA-912446": "Meiotic recombination", "R-HSA-9612973": "Autophagy", "R-HSA-9663891": "Selective autophagy", "R-HSA-9664873": "Pexophagy", "R-HSA-9675135": "Diseases of DNA repair", "R-HSA-9675136": "Diseases of DNA Double-Strand Break Repair", "R-HSA-9701190": "Defective homologous recombination repair (HRR) due to BRCA2 loss of function", "R-HSA-9701192": "Defective homologous recombination repair (HRR) due to BRCA1 loss of function", "R-HSA-9701193": "Defective homologous recombination repair (HRR) due to PALB2 loss of function", "R-HSA-9704331": "Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function", "R-HSA-9704646": "Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function", "R-HSA-9709570": "Impaired BRCA2 binding to RAD51", "R-HSA-9709603": "Impaired BRCA2 binding to PALB2", "R-HSA-4411364": "Binding of TCF/LEF:CTNNB1 to target gene promoters", "R-HSA-4641265": "Repression of WNT target genes", "R-HSA-9943962": "CHD6, CHD7, CHD8, CHD9 subfamily", "R-HSA-74158": "RNA Polymerase III Transcription", "R-HSA-749476": "RNA Polymerase III Abortive And Retractive Initiation", "R-HSA-76046": "RNA Polymerase III Transcription Initiation", "R-HSA-76061": "RNA Polymerase III Transcription Initiation From Type 1 Promoter", "R-HSA-76066": "RNA Polymerase III Transcription Initiation From Type 2 Promoter", "R-HSA-76071": "RNA Polymerase III Transcription Initiation From Type 3 Promoter", "R-HSA-9008059": "Interleukin-37 signaling", "R-HSA-1368108": "BMAL1:CLOCK,NPAS2 activates circadian expression", "R-HSA-1989781": "PPARA activates gene expression", "R-HSA-400206": "Regulation of lipid metabolism by PPARalpha", "R-HSA-9707616": "Heme signaling", "R-HSA-9931509": "Expression of BMAL (ARNTL), CLOCK, and NPAS2", "R-HSA-9931510": "Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes", "R-HSA-9931512": "Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters", "R-HSA-9931521": "The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex", "R-HSA-9931529": "Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK", "R-HSA-9754189": "Germ layer formation at gastrulation", "R-HSA-9758920": "Formation of lateral plate mesoderm", "R-HSA-9761174": "Formation of intermediate mesoderm", "R-HSA-9827857": "Specification of primordial germ cells", "R-HSA-9830364": "Formation of the nephric duct", "R-HSA-9830369": "Kidney development", "R-HSA-9830674": "Formation of the ureteric bud", "R-HSA-9834899": "Specification of the neural plate border", "R-HSA-112308": "Presynaptic depolarization and calcium channel opening", "R-HSA-9717189": "Sensory perception of taste", "R-HSA-9717207": "Sensory perception of sweet, bitter, and umami (glutamate) taste", "R-HSA-9730628": "Sensory perception of salty taste", "R-HSA-6805567": "Keratinization", "R-HSA-6809371": "Formation of the cornified envelope", "R-HSA-420499": "Class C/3 (Metabotropic glutamate/pheromone receptors)", "R-HSA-73762": "RNA Polymerase I Transcription Initiation", "R-HSA-73772": "RNA Polymerase I Promoter Escape", "R-HSA-73863": "RNA Polymerase I Transcription Termination", "R-HSA-73864": "RNA Polymerase I Transcription", "R-HSA-163560": "Triglyceride catabolism", "R-HSA-202131": "Metabolism of nitric oxide: NOS3 activation and regulation", "R-HSA-203615": "eNOS activation", "R-HSA-203641": "NOSTRIN mediated eNOS trafficking", "R-HSA-209776": "Metabolism of amine-derived hormones", "R-HSA-209968": "Thyroxine biosynthesis", "R-HSA-210991": "Basigin interactions", "R-HSA-4641262": "Disassembly of the destruction complex and recruitment of AXIN to the membrane", "R-HSA-5218920": "VEGFR2 mediated vascular permeability", "R-HSA-8979227": "Triglyceride metabolism", "R-HSA-8980692": "RHOA GTPase cycle", "R-HSA-9013026": "RHOB GTPase cycle", "R-HSA-9013106": "RHOC GTPase cycle", "R-HSA-9013148": "CDC42 GTPase cycle", "R-HSA-9013149": "RAC1 GTPase cycle", "R-HSA-9013404": "RAC2 GTPase cycle", "R-HSA-9013405": "RHOD GTPase cycle", "R-HSA-9013406": "RHOQ GTPase cycle", "R-HSA-9013407": "RHOH GTPase cycle", "R-HSA-9013408": "RHOG GTPase cycle", "R-HSA-9013409": "RHOJ GTPase cycle", "R-HSA-9013423": "RAC3 GTPase cycle", "R-HSA-9617828": "FOXO-mediated transcription of cell cycle genes", "R-HSA-9678108": "SARS-CoV-1 Infection", "R-HSA-9692914": "SARS-CoV-1-host interactions", "R-HSA-9696264": "RND3 GTPase cycle", "R-HSA-9696270": "RND2 GTPase cycle", "R-HSA-9696273": "RND1 GTPase cycle", "R-HSA-9705683": "SARS-CoV-2-host interactions", "R-HSA-9735871": "SARS-CoV-1 targets host intracellular signalling and regulatory pathways", "R-HSA-9755779": "SARS-CoV-2 targets host intracellular signalling and regulatory pathways", "R-HSA-427389": "ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression", "R-HSA-8953750": "Transcriptional Regulation by E2F6", "R-HSA-113507": "E2F-enabled inhibition of pre-replication complex formation", "R-HSA-113510": "E2F mediated regulation of DNA replication", "R-HSA-156711": "Polo-like kinase mediated events", "R-HSA-162658": "Golgi Cisternae Pericentriolar Stack Reorganization", "R-HSA-174048": "APC/C:Cdc20 mediated degradation of Cyclin B", "R-HSA-176412": "Phosphorylation of the APC/C", "R-HSA-176417": "Phosphorylation of Emi1", "R-HSA-2299718": "Condensation of Prophase Chromosomes", "R-HSA-2465910": "MASTL Facilitates Mitotic Progression", "R-HSA-2500257": "Resolution of Sister Chromatid Cohesion", "R-HSA-2514853": "Condensation of Prometaphase Chromosomes", "R-HSA-2980766": "Nuclear Envelope Breakdown", "R-HSA-2980767": "Activation of NIMA Kinases NEK9, NEK6, NEK7", "R-HSA-2995383": "Initiation of Nuclear Envelope (NE) Reformation", "R-HSA-2995410": "Nuclear Envelope (NE) Reassembly", "R-HSA-3301854": "Nuclear Pore Complex (NPC) Disassembly", "R-HSA-4419969": "Depolymerization of the Nuclear Lamina", "R-HSA-68875": "Mitotic Prophase", "R-HSA-69273": "Cyclin A/B1/B2 associated events during G2/M transition", "R-HSA-69478": "G2/M DNA replication checkpoint", "R-HSA-75035": "Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex", "R-HSA-9825892": "Regulation of MITF-M-dependent genes involved in cell cycle and proliferation", "R-HSA-2122947": "NOTCH1 Intracellular Domain Regulates Transcription", "R-HSA-2173793": "Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer", "R-HSA-2173796": "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription", "R-HSA-140534": "Caspase activation via Death Receptors in the presence of ligand", "R-HSA-166020": "Transfer of LPS from LBP carrier to CD14", "R-HSA-2562578": "TRIF-mediated programmed cell death", "R-HSA-5357769": "Caspase activation via extrinsic apoptotic signalling pathway", "R-HSA-5602358": "Diseases associated with the TLR signaling cascade", "R-HSA-5602498": "MyD88 deficiency (TLR2/4)", "R-HSA-5603041": "IRAK4 deficiency (TLR2/4)", "R-HSA-5686938": "Regulation of TLR by endogenous ligand", "R-HSA-936964": "Activation of IRF3, IRF7 mediated by TBK1, IKK\u03b5 (IKBKE)", "R-HSA-937072": "TRAF6-mediated induction of TAK1 complex within TLR4 complex", "R-HSA-975163": "IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation", "R-HSA-9824878": "Regulation of TBK1, IKK\u03b5 (IKBKE)-mediated activation of IRF3, IRF7 ", "R-HSA-9937850": "NuRD complex assembly", "R-HSA-9940951": "Interaction of NuRD complexes with transcription factors", "R-HSA-141424": "Amplification of signal from the kinetochores", "R-HSA-141444": "Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal", "R-HSA-606279": "Deposition of new CENPA-containing nucleosomes at the centromere", "R-HSA-69618": "Mitotic Spindle Checkpoint", "R-HSA-774815": "Nucleosome assembly", "R-HSA-9648025": "EML4 and NUDC in mitotic spindle formation", "R-HSA-2132295": "MHC class II antigen presentation", "R-HSA-6811434": "COPI-dependent Golgi-to-ER retrograde traffic", "R-HSA-6811442": "Intra-Golgi and retrograde Golgi-to-ER traffic", "R-HSA-8856688": "Golgi-to-ER retrograde transport", "R-HSA-983189": "Kinesins", "R-HSA-9979719": "Processing of antigen in germinal center B cells", "R-HSA-181431": "Acetylcholine binding and downstream events", "R-HSA-622323": "Presynaptic nicotinic acetylcholine receptors", "R-HSA-622327": "Postsynaptic nicotinic acetylcholine receptors", "R-HSA-629594": "Highly calcium permeable postsynaptic nicotinic acetylcholine receptors", "R-HSA-629597": "Highly calcium permeable nicotinic acetylcholine receptors", "R-HSA-420029": "Tight junction interactions", "R-HSA-211897": "Cytochrome P450 - arranged by substrate type", "R-HSA-211935": "Fatty acids", "R-HSA-211958": "Miscellaneous substrates", "R-HSA-211981": "Xenobiotics", "R-HSA-211999": "CYP2E1 reactions", "R-HSA-9018677": "Biosynthesis of DHA-derived SPMs", "R-HSA-9018678": "Biosynthesis of specialized proresolving mediators (SPMs)", "R-HSA-9018682": "Biosynthesis of maresins", "R-HSA-9027307": "Biosynthesis of maresin-like SPMs", "R-HSA-201556": "Signaling by ALK", "R-HSA-4655427": "SUMOylation of DNA methylation proteins", "R-HSA-5334118": "DNA methylation", "R-HSA-9701898": "STAT3 nuclear events downstream of ALK signaling", "R-HSA-9710421": "Defective pyroptosis", "R-HSA-9752946": "Expression and translocation of olfactory receptors", "R-HSA-1296071": "Potassium Channels", "R-HSA-1296072": "Voltage gated Potassium channels", "R-HSA-189200": "Cellular hexose transport", "R-HSA-425407": "SLC-mediated transmembrane transport", "R-HSA-8963889": "Assembly of active LPL and LIPC lipase complexes", "R-HSA-9821993": "Replacement of protamines by nucleosomes in the male pronucleus", "R-HSA-427359": "SIRT1 negatively regulates rRNA expression", "R-HSA-68616": "Assembly of the ORC complex at the origin of replication", "R-HSA-73728": "RNA Polymerase I Promoter Opening", "R-HSA-9764725": "Negative Regulation of CDH1 Gene Transcription", "R-HSA-9943411": "CHD1 and CHD2 subfamily", "R-HSA-389397": "Orexin and neuropeptides FF and QRFP bind to their respective receptors", "R-HSA-390666": "Serotonin receptors", "R-HSA-112311": "Neurotransmitter clearance", "R-HSA-380615": "Serotonin clearance from the synaptic cleft", "R-HSA-442660": "SLC-mediated transport of neurotransmitters", "R-HSA-4755510": "SUMOylation of immune response proteins", "R-HSA-9013973": "TICAM1-dependent activation of IRF3/IRF7", "R-HSA-918233": "TRAF3-dependent IRF activation pathway", "R-HSA-933541": "TRAF6 mediated IRF7 activation", "R-HSA-936440": "Negative regulators of DDX58/IFIH1 signaling", "R-HSA-9692916": "SARS-CoV-1 activates/modulates innate immune responses", "R-HSA-9705671": "SARS-CoV-2 activates/modulates innate and adaptive immune responses", "R-HSA-9828211": "Regulation of TBK1, IKK\u03b5-mediated activation of IRF3, IRF7 upon TLR3 ligation", "R-HSA-9920588": "Dengue virus activates/modulates innate and adaptive immune responses", "R-HSA-110313": "Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template", "R-HSA-1169408": "ISG15 antiviral mechanism", "R-HSA-168276": "NS1 Mediated Effects on Host Pathways", "R-HSA-5656169": "Termination of translesion DNA synthesis", "R-HSA-73893": "DNA Damage Bypass", "R-HSA-909733": "Interferon alpha/beta signaling", "R-HSA-9909505": "Modulation of host responses by IFN-stimulated genes", "R-HSA-1296041": "Activation of G protein gated Potassium channels", "R-HSA-1296053": "Classical Kir channels", "R-HSA-1296059": "G protein gated Potassium channels", "R-HSA-1296065": "Inwardly rectifying K+ channels", "R-HSA-5576886": "Phase 4 - resting membrane potential", "R-HSA-997272": "Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits", "R-HSA-419408": "Lysosphingolipid and LPA receptors", "R-HSA-1482788": "Acyl chain remodelling of PC", "R-HSA-1482801": "Acyl chain remodelling of PS", "R-HSA-110312": "Translesion synthesis by REV1", "R-HSA-5655862": "Translesion synthesis by POLK", "R-HSA-5656121": "Translesion synthesis by POLI", "R-HSA-9968295": "Somatic hypermutation of immunoglobulin genes by error-prone mismatch repair (MMR)", "R-HSA-9968297": "Somatic hypermutation of immunoglobulin genes by error-prone base excision repair (BER)", "R-HSA-448424": "Interleukin-17 signaling", "R-HSA-450294": "MAP kinase activation", "R-HSA-450302": "activated TAK1 mediates p38 MAPK activation", "R-HSA-450321": "JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1", "R-HSA-9014325": "TICAM1,TRAF6-dependent induction of TAK1 complex", "R-HSA-937042": "IRAK2 mediated activation of TAK1 complex", "R-HSA-549127": "SLC-mediated transport of organic cations", "R-HSA-8963676": "Intestinal absorption", "R-HSA-8981373": "Intestinal hexose absorption", "R-HSA-1483249": "Inositol phosphate metabolism", "R-HSA-159227": "Transport of the SLBP independent Mature mRNA", "R-HSA-159230": "Transport of the SLBP Dependant Mature mRNA", "R-HSA-159231": "Transport of Mature mRNA Derived from an Intronless Transcript", "R-HSA-159234": "Transport of Mature mRNAs Derived from Intronless Transcripts", "R-HSA-159236": "Transport of Mature mRNA derived from an Intron-Containing Transcript", "R-HSA-162599": "Late Phase of HIV Life Cycle", "R-HSA-165054": "Rev-mediated nuclear export of HIV RNA", "R-HSA-168271": "Transport of Ribonucleoproteins into the Host Nucleus", "R-HSA-168273": "Influenza Viral RNA Transcription and Replication", "R-HSA-168274": "Export of Viral Ribonucleoproteins from Nucleus", "R-HSA-168325": "Viral Messenger RNA Synthesis", "R-HSA-168333": "NEP/NS2 Interacts with the Cellular Export Machinery", "R-HSA-170822": "Regulation of Glucokinase by Glucokinase Regulatory Protein", "R-HSA-176033": "Interactions of Vpr with host cellular proteins", "R-HSA-177243": "Interactions of Rev with host cellular proteins", "R-HSA-180746": "Nuclear import of Rev protein", "R-HSA-180910": "Vpr-mediated nuclear import of PICs", "R-HSA-1855170": "IPs transport between nucleus and cytosol", "R-HSA-1855196": "IP3 and IP4 transport between cytosol and nucleus", "R-HSA-1855229": "IP6 and IP7 transport between cytosol and nucleus", "R-HSA-191859": "snRNP Assembly", "R-HSA-194441": "Metabolism of non-coding RNA", "R-HSA-3108214": "SUMOylation of DNA damage response and repair proteins", "R-HSA-3232142": "SUMOylation of ubiquitinylation proteins", "R-HSA-4085377": "SUMOylation of SUMOylation proteins", "R-HSA-4551638": "SUMOylation of chromatin organization proteins", "R-HSA-4570464": "SUMOylation of RNA binding proteins", "R-HSA-4615885": "SUMOylation of DNA replication proteins", "R-HSA-5619102": "SLC transporter disorders", "R-HSA-5619107": "Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)", "R-HSA-6784531": "tRNA processing in the nucleus", "R-HSA-70171": "Glycolysis", "R-HSA-70326": "Glucose metabolism", "R-HSA-72202": "Transport of Mature Transcript to Cytoplasm", "R-HSA-72203": "Processing of Capped Intron-Containing Pre-mRNA", "R-HSA-72306": "tRNA processing", "R-HSA-9610379": "HCMV Late Events", "R-HSA-6790901": "rRNA modification in the nucleus and cytosol", "R-HSA-6791226": "Major pathway of rRNA processing in the nucleolus and cytosol", "R-HSA-72312": "rRNA processing", "R-HSA-8868773": "rRNA processing in the nucleus and cytosol"}