{
  "schema": "https://aptatlas.org/data/v4.6/pathway_coverage.schema.json",
  "name": "pathway_coverage",
  "title": "Pathway coverage",
  "version": "4.6",
  "last_updated": "2026-11-04",
  "licence": "CC-BY-4.0",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "citation": "Whelan CD, Smith-Byrne K. Atlas of Proteomic Technologies: an evidence-based framework for selecting and combining commercial proteomics platforms. bioRxiv 2026. https://doi.org/10.64898/2026.09.10.750723",
  "archive_doi": "10.5281/zenodo.22697191",
  "third_party": [
    {
      "name": "Reactome",
      "licence": "CC0-1.0",
      "url": "https://reactome.org/license",
      "relationship": "source",
      "note": "Pathway membership."
    }
  ],
  "data": {
    "schema_version": 1,
    "note": "Per-pathway coverage percentages, precomputed. single = one platform; pair keys are 'platformA|platformB' using the same platform ids as choose_engine_spec.json.",
    "denominator": "pathway members present in the canonical proteome (not restricted to the detectable proteome)",
    "platform_ids": [
      "seer-proteograph",
      "illumina-protein-prep",
      "olink-explore-ht",
      "biognosys-truediscovery",
      "nomic-omni",
      "nulisa"
    ],
    "single": {
      "R-HSA-76005": {
        "seer-proteograph": 95.3,
        "illumina-protein-prep": 83.5,
        "olink-explore-ht": 50.4,
        "biognosys-truediscovery": 78,
        "nomic-omni": 37,
        "nulisa": 15.7
      },
      "R-HSA-6798695": {
        "seer-proteograph": 95.4,
        "illumina-protein-prep": 73.4,
        "olink-explore-ht": 42.8,
        "biognosys-truediscovery": 69.4,
        "nomic-omni": 22,
        "nulisa": 7.5
      },
      "R-HSA-114608": {
        "seer-proteograph": 95.9,
        "illumina-protein-prep": 82.6,
        "olink-explore-ht": 51.2,
        "biognosys-truediscovery": 78.5,
        "nomic-omni": 38.8,
        "nulisa": 15.7
      },
      "R-HSA-9855719": {
        "seer-proteograph": 90,
        "illumina-protein-prep": 90,
        "olink-explore-ht": 60,
        "biognosys-truediscovery": 90,
        "nomic-omni": 50,
        "nulisa": 20
      },
      "R-HSA-1474228": {
        "seer-proteograph": 78.3,
        "illumina-protein-prep": 74.8,
        "olink-explore-ht": 46.2,
        "biognosys-truediscovery": 58,
        "nomic-omni": 30.1,
        "nulisa": 9.1
      },
      "R-HSA-9970672": {
        "seer-proteograph": 32.3,
        "illumina-protein-prep": 35.5,
        "olink-explore-ht": 22.6,
        "biognosys-truediscovery": 32.3,
        "nomic-omni": 16.1,
        "nulisa": 6.5
      },
      "R-HSA-9840309": {
        "seer-proteograph": 68.4,
        "illumina-protein-prep": 68.4,
        "olink-explore-ht": 10.5,
        "biognosys-truediscovery": 36.8,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-5173105": {
        "seer-proteograph": 58,
        "illumina-protein-prep": 58,
        "olink-explore-ht": 29.8,
        "biognosys-truediscovery": 45,
        "nomic-omni": 12.2,
        "nulisa": 1.5
      },
      "R-HSA-168255": {
        "seer-proteograph": 86.2,
        "illumina-protein-prep": 48.8,
        "olink-explore-ht": 13.8,
        "biognosys-truediscovery": 38.2,
        "nomic-omni": 3.3,
        "nulisa": 1.6
      },
      "R-HSA-3301854": {
        "seer-proteograph": 86.5,
        "illumina-protein-prep": 40.5,
        "olink-explore-ht": 18.9,
        "biognosys-truediscovery": 10.8,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-8980692": {
        "seer-proteograph": 72.7,
        "illumina-protein-prep": 51,
        "olink-explore-ht": 39.2,
        "biognosys-truediscovery": 25.9,
        "nomic-omni": 2.8,
        "nulisa": 0
      },
      "R-HSA-159231": {
        "seer-proteograph": 97.6,
        "illumina-protein-prep": 40.5,
        "olink-explore-ht": 26.2,
        "biognosys-truediscovery": 9.5,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-6784531": {
        "seer-proteograph": 86.8,
        "illumina-protein-prep": 37.7,
        "olink-explore-ht": 13.2,
        "biognosys-truediscovery": 13.2,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-168274": {
        "seer-proteograph": 96.9,
        "illumina-protein-prep": 43.8,
        "olink-explore-ht": 21.9,
        "biognosys-truediscovery": 12.5,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-168273": {
        "seer-proteograph": 86.4,
        "illumina-protein-prep": 42.7,
        "olink-explore-ht": 11.7,
        "biognosys-truediscovery": 33,
        "nomic-omni": 1.9,
        "nulisa": 1
      },
      "R-HSA-1855229": {
        "seer-proteograph": 96.7,
        "illumina-protein-prep": 40,
        "olink-explore-ht": 20,
        "biognosys-truediscovery": 6.7,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-4615885": {
        "seer-proteograph": 84.8,
        "illumina-protein-prep": 52.2,
        "olink-explore-ht": 28.3,
        "biognosys-truediscovery": 13,
        "nomic-omni": 4.3,
        "nulisa": 0
      },
      "R-HSA-72202": {
        "seer-proteograph": 90.4,
        "illumina-protein-prep": 44.6,
        "olink-explore-ht": 19.3,
        "biognosys-truediscovery": 10.8,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-3232142": {
        "seer-proteograph": 89.5,
        "illumina-protein-prep": 44.7,
        "olink-explore-ht": 18.4,
        "biognosys-truediscovery": 7.9,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-70171": {
        "seer-proteograph": 95.8,
        "illumina-protein-prep": 63.9,
        "olink-explore-ht": 26.4,
        "biognosys-truediscovery": 40.3,
        "nomic-omni": 1.4,
        "nulisa": 2.8
      },
      "R-HSA-159230": {
        "seer-proteograph": 94.4,
        "illumina-protein-prep": 47.2,
        "olink-explore-ht": 22.2,
        "biognosys-truediscovery": 11.1,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-165054": {
        "seer-proteograph": 97.1,
        "illumina-protein-prep": 47.1,
        "olink-explore-ht": 26.5,
        "biognosys-truediscovery": 14.7,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-159234": {
        "seer-proteograph": 95.3,
        "illumina-protein-prep": 41.9,
        "olink-explore-ht": 25.6,
        "biognosys-truediscovery": 9.3,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-191859": {
        "seer-proteograph": 87,
        "illumina-protein-prep": 51.9,
        "olink-explore-ht": 24.1,
        "biognosys-truediscovery": 9.3,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-3108214": {
        "seer-proteograph": 84,
        "illumina-protein-prep": 46.7,
        "olink-explore-ht": 28,
        "biognosys-truediscovery": 6.7,
        "nomic-omni": 2.7,
        "nulisa": 1.3
      },
      "R-HSA-168276": {
        "seer-proteograph": 90.5,
        "illumina-protein-prep": 50,
        "olink-explore-ht": 19,
        "biognosys-truediscovery": 16.7,
        "nomic-omni": 2.4,
        "nulisa": 0
      },
      "R-HSA-162599": {
        "seer-proteograph": 81.7,
        "illumina-protein-prep": 51.9,
        "olink-explore-ht": 19.1,
        "biognosys-truediscovery": 16.8,
        "nomic-omni": 0,
        "nulisa": 1.5
      },
      "R-HSA-2980766": {
        "seer-proteograph": 89.1,
        "illumina-protein-prep": 49.1,
        "olink-explore-ht": 16.4,
        "biognosys-truediscovery": 20,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-9610379": {
        "seer-proteograph": 69.7,
        "illumina-protein-prep": 40.8,
        "olink-explore-ht": 17.1,
        "biognosys-truediscovery": 18.4,
        "nomic-omni": 1.3,
        "nulisa": 0
      },
      "R-HSA-159236": {
        "seer-proteograph": 90.5,
        "illumina-protein-prep": 45.9,
        "olink-explore-ht": 16.2,
        "biognosys-truediscovery": 10.8,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-9705671": {
        "seer-proteograph": 77.8,
        "illumina-protein-prep": 61.9,
        "olink-explore-ht": 32.5,
        "biognosys-truediscovery": 26.2,
        "nomic-omni": 13.5,
        "nulisa": 7.1
      },
      "R-HSA-180746": {
        "seer-proteograph": 97.1,
        "illumina-protein-prep": 47.1,
        "olink-explore-ht": 23.5,
        "biognosys-truediscovery": 14.7,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-159227": {
        "seer-proteograph": 97.1,
        "illumina-protein-prep": 45.7,
        "olink-explore-ht": 22.9,
        "biognosys-truediscovery": 11.4,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-168333": {
        "seer-proteograph": 96.8,
        "illumina-protein-prep": 41.9,
        "olink-explore-ht": 19.4,
        "biognosys-truediscovery": 9.7,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-72203": {
        "seer-proteograph": 90,
        "illumina-protein-prep": 52.6,
        "olink-explore-ht": 21.1,
        "biognosys-truediscovery": 13.5,
        "nomic-omni": 0.7,
        "nulisa": 0.3
      },
      "R-HSA-1855170": {
        "seer-proteograph": 96.7,
        "illumina-protein-prep": 40,
        "olink-explore-ht": 20,
        "biognosys-truediscovery": 6.7,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-9609690": {
        "seer-proteograph": 68,
        "illumina-protein-prep": 41,
        "olink-explore-ht": 18,
        "biognosys-truediscovery": 16,
        "nomic-omni": 2,
        "nulisa": 2
      },
      "R-HSA-4570464": {
        "seer-proteograph": 87.5,
        "illumina-protein-prep": 45.8,
        "olink-explore-ht": 22.9,
        "biognosys-truediscovery": 12.5,
        "nomic-omni": 2.1,
        "nulisa": 0
      },
      "R-HSA-168325": {
        "seer-proteograph": 92.9,
        "illumina-protein-prep": 45.2,
        "olink-explore-ht": 16.7,
        "biognosys-truediscovery": 4.8,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-168271": {
        "seer-proteograph": 96.9,
        "illumina-protein-prep": 43.8,
        "olink-explore-ht": 18.8,
        "biognosys-truediscovery": 9.4,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-4085377": {
        "seer-proteograph": 94.3,
        "illumina-protein-prep": 42.9,
        "olink-explore-ht": 20,
        "biognosys-truediscovery": 11.4,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-3371453": {
        "seer-proteograph": 82.9,
        "illumina-protein-prep": 59.8,
        "olink-explore-ht": 32.9,
        "biognosys-truediscovery": 31.7,
        "nomic-omni": 9.8,
        "nulisa": 3.7
      },
      "R-HSA-68875": {
        "seer-proteograph": 68.9,
        "illumina-protein-prep": 39.6,
        "olink-explore-ht": 15.1,
        "biognosys-truediscovery": 20.8,
        "nomic-omni": 0.9,
        "nulisa": 0
      },
      "R-HSA-170822": {
        "seer-proteograph": 96.9,
        "illumina-protein-prep": 43.8,
        "olink-explore-ht": 21.9,
        "biognosys-truediscovery": 6.2,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-180910": {
        "seer-proteograph": 97.1,
        "illumina-protein-prep": 44.1,
        "olink-explore-ht": 20.6,
        "biognosys-truediscovery": 8.8,
        "nomic-omni": 2.9,
        "nulisa": 0
      },
      "R-HSA-4551638": {
        "seer-proteograph": 81,
        "illumina-protein-prep": 50,
        "olink-explore-ht": 19,
        "biognosys-truediscovery": 8.6,
        "nomic-omni": 1.7,
        "nulisa": 0
      },
      "R-HSA-5619107": {
        "seer-proteograph": 96.9,
        "illumina-protein-prep": 43.8,
        "olink-explore-ht": 21.9,
        "biognosys-truediscovery": 6.2,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-1169408": {
        "seer-proteograph": 89.3,
        "illumina-protein-prep": 64,
        "olink-explore-ht": 30.7,
        "biognosys-truediscovery": 29.3,
        "nomic-omni": 5.3,
        "nulisa": 1.3
      },
      "R-HSA-1855196": {
        "seer-proteograph": 96.7,
        "illumina-protein-prep": 40,
        "olink-explore-ht": 20,
        "biognosys-truediscovery": 6.7,
        "nomic-omni": 0,
        "nulisa": 0
      },
      "R-HSA-8856828": {
        "seer-proteograph": 81.3,
        "illumina-protein-prep": 79.1,
        "olink-explore-ht": 42.5,
        "biognosys-truediscovery": 48.5,
        "nomic-omni": 12.7,
        "nulisa": 4.5
      },
      "R-HSA-8856825": {
        "seer-proteograph": 74.7,
        "illumina-protein-prep": 75.8,
        "olink-explore-ht": 45.3,
        "biognosys-truediscovery": 42.1,
        "nomic-omni": 16.8,
        "nulisa": 6.3
      },
      "R-HSA-177929": {
        "seer-proteograph": 75.5,
        "illumina-protein-prep": 79.2,
        "olink-explore-ht": 52.8,
        "biognosys-truediscovery": 39.6,
        "nomic-omni": 26.4,
        "nulisa": 7.5
      },
      "R-HSA-168638": {
        "seer-proteograph": 75,
        "illumina-protein-prep": 63.9,
        "olink-explore-ht": 47.2,
        "biognosys-truediscovery": 19.4,
        "nomic-omni": 13.9,
        "nulisa": 5.6
      },
      "R-HSA-194138": {
        "seer-proteograph": 90.8,
        "illumina-protein-prep": 72.4,
        "olink-explore-ht": 35.7,
        "biognosys-truediscovery": 43.9,
        "nomic-omni": 16.3,
        "nulisa": 8.2
      },
      "R-HSA-400206": {
        "seer-proteograph": 56.2,
        "illumina-protein-prep": 53.7,
        "olink-explore-ht": 28.1,
        "biognosys-truediscovery": 14.9,
        "nomic-omni": 9.1,
        "nulisa": 2.5
      },
      "R-HSA-1989781": {
        "seer-proteograph": 56.3,
        "illumina-protein-prep": 54.6,
        "olink-explore-ht": 27.7,
        "biognosys-truediscovery": 15.1,
        "nomic-omni": 9.2,
        "nulisa": 2.5
      },
      "R-HSA-9029569": {
        "seer-proteograph": 71.1,
        "illumina-protein-prep": 57.9,
        "olink-explore-ht": 26.3,
        "biognosys-truediscovery": 21.1,
        "nomic-omni": 5.3,
        "nulisa": 2.6
      },
      "R-HSA-382556": {
        "seer-proteograph": 72.2,
        "illumina-protein-prep": 56.7,
        "olink-explore-ht": 17.8,
        "biognosys-truediscovery": 42.2,
        "nomic-omni": 2.2,
        "nulisa": 2.2
      },
      "R-HSA-9615017": {
        "seer-proteograph": 76.7,
        "illumina-protein-prep": 80,
        "olink-explore-ht": 50,
        "biognosys-truediscovery": 20,
        "nomic-omni": 20,
        "nulisa": 10
      },
      "R-HSA-212436": {
        "seer-proteograph": 44.1,
        "illumina-protein-prep": 48.5,
        "olink-explore-ht": 22.9,
        "biognosys-truediscovery": 13.6,
        "nomic-omni": 6.4,
        "nulisa": 2.6
      },
      "R-HSA-9614085": {
        "seer-proteograph": 69.7,
        "illumina-protein-prep": 78.8,
        "olink-explore-ht": 45.5,
        "biognosys-truediscovery": 22.7,
        "nomic-omni": 22.7,
        "nulisa": 9.1
      },
      "R-HSA-9757110": {
        "seer-proteograph": 70,
        "illumina-protein-prep": 70,
        "olink-explore-ht": 30,
        "biognosys-truediscovery": 40,
        "nomic-omni": 10,
        "nulisa": 0
      },
      "R-HSA-159418": {
        "seer-proteograph": 57.9,
        "illumina-protein-prep": 47.4,
        "olink-explore-ht": 15.8,
        "biognosys-truediscovery": 15.8,
        "nomic-omni": 5.3,
        "nulisa": 0
      },
      "R-HSA-9707564": {
        "seer-proteograph": 71.7,
        "illumina-protein-prep": 55,
        "olink-explore-ht": 23.3,
        "biognosys-truediscovery": 11.7,
        "nomic-omni": 13.3,
        "nulisa": 3.3
      },
      "R-HSA-9759194": {
        "seer-proteograph": 84.1,
        "illumina-protein-prep": 81.8,
        "olink-explore-ht": 34.1,
        "biognosys-truediscovery": 63.6,
        "nomic-omni": 15.9,
        "nulisa": 9.1
      },
      "R-HSA-189483": {
        "seer-proteograph": 94.1,
        "illumina-protein-prep": 70.6,
        "olink-explore-ht": 41.2,
        "biognosys-truediscovery": 35.3,
        "nomic-omni": 23.5,
        "nulisa": 5.9
      },
      "R-HSA-9755511": {
        "seer-proteograph": 82.1,
        "illumina-protein-prep": 79.5,
        "olink-explore-ht": 33.9,
        "biognosys-truediscovery": 57.1,
        "nomic-omni": 14.3,
        "nulisa": 7.1
      },
      "R-HSA-9749641": {
        "seer-proteograph": 64.4,
        "illumina-protein-prep": 60,
        "olink-explore-ht": 17.8,
        "biognosys-truediscovery": 15.6,
        "nomic-omni": 8.9,
        "nulisa": 0
      },
      "R-HSA-422356": {
        "seer-proteograph": 63.6,
        "illumina-protein-prep": 41.6,
        "olink-explore-ht": 28.6,
        "biognosys-truediscovery": 31.2,
        "nomic-omni": 2.6,
        "nulisa": 2.6
      },
      "R-HSA-9013106": {
        "seer-proteograph": 77.5,
        "illumina-protein-prep": 57.7,
        "olink-explore-ht": 42.3,
        "biognosys-truediscovery": 32.4,
        "nomic-omni": 4.2,
        "nulisa": 0
      },
      "R-HSA-909733": {
        "seer-proteograph": 63.2,
        "illumina-protein-prep": 72.4,
        "olink-explore-ht": 23.7,
        "biognosys-truediscovery": 30.3,
        "nomic-omni": 11.8,
        "nulisa": 5.3
      },
      "R-HSA-8964058": {
        "seer-proteograph": 80,
        "illumina-protein-prep": 90,
        "olink-explore-ht": 30,
        "biognosys-truediscovery": 80,
        "nomic-omni": 40,
        "nulisa": 20
      },
      "R-HSA-189451": {
        "seer-proteograph": 73.3,
        "illumina-protein-prep": 66.7,
        "olink-explore-ht": 33.3,
        "biognosys-truediscovery": 40,
        "nomic-omni": 6.7,
        "nulisa": 0
      },
      "R-HSA-416476": {
        "seer-proteograph": 50.2,
        "illumina-protein-prep": 45.7,
        "olink-explore-ht": 20.1,
        "biognosys-truediscovery": 16.4,
        "nomic-omni": 10.5,
        "nulisa": 3.7
      },
      "R-HSA-5673001": {
        "seer-proteograph": 67.9,
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